Molecular mechanisms of subretinal fibrosis in age-related macular degeneration
Subretinal fibrosis is a result of a wound healing response that follows choroidal
neovascularization in neovascular age-related macular degeneration (nAMD). Although anti …
neovascularization in neovascular age-related macular degeneration (nAMD). Although anti …
Innate immune response in retinal homeostasis and inflammatory disorders
Y Murakami, K Ishikawa, S Nakao… - Progress in retinal and eye …, 2020 - Elsevier
Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are
pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis …
pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis …
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa
N Yoshida, Y Ikeda, S Notomi, K Ishikawa, Y Murakami… - Ophthalmology, 2013 - Elsevier
PURPOSE: To study the nature of inflammatory reaction in eyes of patients with retinitis
pigmentosa (RP) and its possible role in the pathogenesis of RP. DESIGN: Retrospective …
pigmentosa (RP) and its possible role in the pathogenesis of RP. DESIGN: Retrospective …
[PDF][PDF] ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying
cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 …
cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 …
[HTML][HTML] The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction
PG Sreekumar, K Ishikawa, C Spee… - … & visual science, 2016 - iovs.arvojournals.org
Purpose: To investigate the expression of humanin (HN) in human retinal pigment epithelial
(hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial …
(hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial …
[HTML][HTML] Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization
Choroidal neovascularization (CNV) is a serious complication of age‑related macular
degeneration. The aim of the present study was to investigate the expression and …
degeneration. The aim of the present study was to investigate the expression and …
[HTML][HTML] Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy
K Ishikawa, S He, H Terasaki, H Nazari, H Zhang… - Scientific reports, 2015 - nature.com
Proliferative vitreoretinopathy (PVR) is a serious complication of retinal detachment and
ocular trauma and its recurrence may lead to irreversible vision loss. Epithelial to …
ocular trauma and its recurrence may lead to irreversible vision loss. Epithelial to …
[HTML][HTML] M2 macrophages enhance pathological neovascularization in the mouse model of oxygen-induced retinopathy
Purpose: To investigate the roles played by M2 macrophages in a mouse model of oxygen-
induced retinopathy (OIR). Methods: Oxygen-induced retinopathy was induced in C57BL/6J …
induced retinopathy (OIR). Methods: Oxygen-induced retinopathy was induced in C57BL/6J …
[HTML][HTML] Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy
K Ishikawa, S Yoshida, Y Kobayashi… - … & visual science, 2015 - tvst.arvojournals.org
Methods.: Six FVMs were surgically removed from patients with proliferative diabetic
retinopathy (PDR) during pars plana vitrectomy with membrane peeling. The FVMs were …
retinopathy (PDR) during pars plana vitrectomy with membrane peeling. The FVMs were …
Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular …
Purpose To determine whether vitreal concentrations of MCP-1, IL-6 and IL-8 are altered
after vitrectomy in patients with proliferative diabetic retinopathy (PDR) and to investigate …
after vitrectomy in patients with proliferative diabetic retinopathy (PDR) and to investigate …