[HTML][HTML] Macular Bruch's membrane defect and dome-shaped macula in high myopia

Y Fang, JB Jonas, T Yokoi, K Cao, K Shinohara… - PLoS …, 2017 - journals.plos.org
Purpose To examine an association between macular Bruch's membrane defects (MBMD)
and a dome-shaped appearance of the macula (DSM). Design Retrospective, observational …

[HTML][HTML] Protection of the retinal ganglion cells: Intravitreal injection of resveratrol in mouse model of ocular hypertension

K Cao, T Ishida, Y Fang, K Shinohara… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: To investigate the efficacy of intravitreal administration of resveratrol (RSV) in a
microbead-induced high intraocular pressure (IOP) murine model for glaucoma. Methods …

Features of posterior staphylomas analyzed in wide-field fundus images in patients with unilateral and bilateral pathologic myopia

K Ohno-Matsui, M Alkabes, C Salinas, C Mateo… - Retina, 2017 - journals.lww.com
Purpose: Pigmentary alterations along the presumed edge of staphyloma in wide-field
fundus images have been reported to be highly correlated with the eye shape in three …

Detection of posterior vortex veins in eyes with pathologic myopia by ultra-widefield indocyanine green angiography

M Moriyama, K Cao, S Ogata… - British Journal of …, 2017 - bjo.bmj.com
Aims To analyse the characteristics of posterior vortex veins detected in highly myopic eyes
by wide-field indocyanine green angiography (ICGA). Methods One hundred and fifty-eight …

[HTML][HTML] Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization

T Ishida, T Yoshida, K Shinohara, K Cao, K Nakahama… - PloS one, 2017 - journals.plos.org
This study investigated the potential role of sirtuin 1 in Müller glial cells in choroidal
neovascularization. In the in vitro study, primary Müller glial cells were cultured and treated …

[HTML][HTML] Visual arrestin modulates gene expression in the retinal pigment epithelium: Implications for homeostasis in the retina

N Nagaoka, T Yoshida, K Cao, Y Iwasaki… - … and Biophysics Reports, 2019 - Elsevier
The retinal pigment epithelium (RPE) is essential for maintaining retinal homeostasis by
removing and recycling photoreceptor outer segment (POS) in membranes. It also produces …

[HTML][HTML] Constructing Murine Model of Posterior Staphyloma Through Targeted Disruption of Bruch's Membrane

K Vutipongsatorn, T Yoshida, X Li… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Pathologic myopia is a leading cause of visual impairment and blindness
especially in East Asia. Its key feature, posterior staphyloma, remains poorly understood with …

The role of Sirt1 for regulating VEGF in human RPE

T Ishida, T Yoshida, K Shinohara… - … & Visual Science, 2015 - iovs.arvojournals.org
Purpose: Retinal pigment epithelium (RPE) is considered a primary site of producing VEGF
for developing choroidal neovascularization (CNV) in age-related macular degeneration …