In February 1999, a workshop was held in Cortina, Italy to develop a consensus defining the
criteria for cure of acromegaly. The workshop was sponsored by the University of Brescia …

Somatotrope function requires consideration of both growth hormone (GH) secretion and
cellular proliferation. The regulation of these processes is, to a large extent, controlled by …

Acromegaly is an insidious disorder caused by a pituitary GH-secreting adenoma resulting
in high circulating levels of GH and IGF-I (1). Unfortunately, no single therapy is …

Disruption of the cyclin-dependent kinase–inhibitory domain of p27 enhances growth of
mice. Growth is attributed to an increase in cell number, due to increased cell proliferation …

Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal
release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on …

To investigate whether the impaired growth hormone secretion associated with obesity is a
result of a hypothalamic or a pituitary disorder and whether it is a cause or a consequence of …

Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein
(AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this …

▪ Objective: To determine the effects of the somatostatin analog, octreotide acetate, in
patients with acromegaly.▪ Design: Double-blind, randomized trial.▪ Setting: Fourteen …

Context: There is currently no medical therapy for Cushing's disease that targets the pituitary
adenoma. Availability of such a medical therapy would be a valuable therapeutic option for …

I. Introduction T HE PERIOD of time spanning the interval between the first postulate of the
existence of a GH-releasing hormone (GRH) and the reports of its isolation and sequence …