Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
KEGG for linking genomes to life and the environment
Abstract KEGG (http://www. genome. jp/kegg/) is a database of biological systems that
integrates genomic, chemical and systemic functional information. KEGG provides a …
integrates genomic, chemical and systemic functional information. KEGG provides a …
Hemodynamic effect of the prone position during anesthesia
M Yokoyama, W Ueda, M Hirakawa… - Acta …, 1991 - Wiley Online Library
We studied 21 patients undergoing lumbar spinal surgery under halothane anesthesia on a
convex saddle frame, in order to determine the hemodynamic effect of the prone position. A …
convex saddle frame, in order to determine the hemodynamic effect of the prone position. A …
From genomics to chemical genomics: new developments in KEGG
The increasing amount of genomic and molecular information is the basis for understanding
higher-order biological systems, such as the cell and the organism, and their interactions …
higher-order biological systems, such as the cell and the organism, and their interactions …
KEGG for representation and analysis of molecular networks involving diseases and drugs
…, M Furumichi, M Tanabe, M Hirakawa - Nucleic acids …, 2010 - academic.oup.com
Most human diseases are complex multi-factorial diseases resulting from the combination of
various genetic and environmental factors. In the KEGG database resource (http://www …
various genetic and environmental factors. In the KEGG database resource (http://www …
[HTML][HTML] Ipilimumab for patients with relapse after allogeneic transplantation
…, JL Hornick, SJ Rodig, M Hirakawa… - … England Journal of …, 2016 - Mass Medical Soc
Background Loss of donor-mediated immune antitumor activity after allogeneic
hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We …
hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We …
[HTML][HTML] Integrative annotation of 21,037 human genes validated by full-length cDNA clones
…, K Homma, A Kasprzyk, T Nishikawa, M Hirakawa… - PLoS …, 2004 - journals.plos.org
The human genome sequence defines our inherent biological potential; the realization of
the biology encoded therein requires knowledge of the function of each gene. Currently, our …
the biology encoded therein requires knowledge of the function of each gene. Currently, our …
Field emission from well-aligned, patterned, carbon nanotube emitters
H Murakami, M Hirakawa, C Tanaka… - Applied Physics …, 2000 - pubs.aip.org
We have developed a process to fabricate well-aligned, patterned, carbon nanotube field
emitters on glass substrates. The process consists of depositing and patterning a nickel …
emitters on glass substrates. The process consists of depositing and patterning a nickel …
[HTML][HTML] Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death
K Tsuruya, T Ninomiya, M Tokumoto, M Hirakawa… - Kidney international, 2003 - Elsevier
Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal
tubular cell death. Background Tumor necrosis factor (TNF) receptor family members, such …
tubular cell death. Background Tumor necrosis factor (TNF) receptor family members, such …
Genetic and phenotypic intra-species variation in Candida albicans
Candida albicans is a commensal fungus of the human gastrointestinal tract and a prevalent
opportunistic pathogen. To examine diversity within this species, extensive genomic and …
opportunistic pathogen. To examine diversity within this species, extensive genomic and …