A brief history of opiates, opioid peptides, and opioid receptors.

MJ Brownstein - Proceedings of the National Academy of …, 1993 - National Acad Sciences
It is hard to decide when and where the opium poppy was first cultivated. It may have been
grown for its seeds before people discovered how to prepare mekonion from the leaves and …

[HTML][HTML] A mammalian microRNA expression atlas based on small RNA library sequencing

P Landgraf, M Rusu, R Sheridan, A Sewer, N Iovino… - Cell, 2007 - cell.com
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

LA Matsuda, SJ Lolait, MJ Brownstein, AC Young… - Nature, 1990 - nature.com
MARIJUANA and many of its constituent cannabinoids influence the central nervous system
(CNS) in a complex and dose-dependent manner1, 2. Although CNS depression and …

A novel class of small RNAs bind to MILI protein in mouse testes

A Aravin, D Gaidatzis, S Pfeffer, M Lagos-Quintana… - Nature, 2006 - nature.com
Abstract Small RNAs bound to Argonaute proteins recognize partially or fully complementary
nucleic acid targets in diverse gene-silencing processes,,,. A subgroup of the Argonaute …

The ubiquitin pathway in Parkinson's disease

E Leroy, R Boyer, G Auburger, B Leube, G Ulm… - Nature, 1998 - nature.com
Mutations of the α-synuclein gene, have been identified in some familial forms of Parkinson's
disease, and α-synuclein protein has been shown to accumulate in the brains of patients …

The genome sequence of taurine cattle: a window to ruminant biology and evolution

Bovine Genome Sequencing and Analysis Consortium… - Science, 2009 - science.org
To understand the biology and evolution of ruminants, the cattle genome was sequenced to
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …

Modulation of Non-Templated Nucleotide Addition by Taq DNA Polymerase: Primer Modifications that Facilitate Genotyping

MJ Brownstein, JD Carpten, JR Smith - Biotechniques, 1996 - Future Science
Taq DNA polymerase can catalyze nontemplated addition of a nucleotide (principally
adenosine) to the 3′ end of PCR-amplified products. Recently, we showed that this activity …

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

JR Smith, D Freije, JD Carpten, H Grönberg, J Xu… - Science, 1996 - science.org
Despite its high prevalence, very little is known regarding genetic predisposition to prostate
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has …

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

E Mezey, A Dehejia, G Harta, MI Papp… - Nature medicine, 1998 - nature.com
Several neurodegenerative disorders are characterized by intracellular protein
accumulations or inclusions, such as the Lewy bodies of Parkinson's disease. Although little …

Synthesis, transport, and release of posterior pituitary hormones

MJ Brownstein, JT Russell, H Gainer - Science, 1980 - science.org
Vasopressin and oxytocin are made and released by neurons of the hypothalamo-
neurohypophysial system. Pulse labeling these neurons with radioactive amino acid …