Emerging evidence indicates that the autofluorescent pigments that accumulate as
lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a …

The retinal pigment epithelium (RPE) is a single layer of post-mitotic cells, which functions
both as a selective barrier to and a vegetative regulator of the overlying photoreceptor layer …

The yellow coloration of the macula lutea is attributable to the presence of macular pigment
in the axons of its photoreceptors. 1 In the 1980s several investigators demonstrated that …

Exposure of the eye to intense light, particularly blue light, can cause irreversible, oxygen-
dependent damage to the retina. However, no key chromophores that trigger such …

Exposure of biological chromophores to ultraviolet radiation can lead to photochemical
damage. However, the role of visible light, particularly in the blue region of the spectrum, has …

The retina represents a paradox, in that, while light and oxygen are essential for vision,
these conditions also favour the formation of reactive oxygen species leading to …

Age-related macular degeneration (AMD) is a major health problem in the developed world
accounting for approximately half of all blind registrations. Current treatment options are …

Pigment epithelium-derived factor (PEDF) has been identified as one of the most potent of
endogenous negative regulators of blood vessel growth in the body. Here we report that …

Despite the association between high concentrations of the age pigment lipofuscin and
various age-related pathologies, there is contention as to whether or not the intracellular …

Accumulation of lipofuscin (LF) is a prominent feature of aging in the human retinal pigment
epithelium (RPE) cells. This age pigment exhibits substantial photoreactivity, which may …