Selective depletion of macrophages from tissues in vivo can be used to investigate whether
these cells are playing a role in defined biological processes. This question is particularly …

Macrophages form an important cell population involved in numerous immunological
processes. Techniques which eliminate these cells, in order to permit 'in vivo'studies of their …

Liposomes encapsulating the bis phosphonate clodronate can be used for the transient
suppression of macrophage functions. Given the important role of macrophages in various …

Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in
the steady state, the dogma remains that tissue macrophages derive from monocytes. Using …

Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert
beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in …

Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …

In salt-sensitive hypertension, the accumulation of Na+ in tissue has been presumed to be
accompanied by a commensurate retention of water to maintain the isotonicity of body fluids …

Although macrophages are widely recognized to have a profibrotic role in inflammation, we
have used a highly tractable CCl4-induced model of reversible hepatic fibrosis to identify …

Macrophages clear pathogens and damaged or aged cells from the blood stream via
phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPα, to …

In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near
osteoblast-lineage cells at the endosteum. To investigate the regulation of these endosteal …