User profiles for "author:Robert Wojciechowski"

Robert Wojciechowski

Johns Hopkins Bloomberg School of Public Health
Verified email at jhu.edu
Cited by 5565

Nature and nurture: the complex genetics of myopia and refractive error

R Wojciechowski - Clinical genetics, 2011 - Wiley Online Library
Wojciechowski R. Nature and nurture: the complex genetics of myopia and refractive error.
The refractive errors, myopia and hyperopia, are optical defects of the visual system that can …

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

VJM Verhoeven, PG Hysi, R Wojciechowski, Q Fan… - Nature …, 2013 - nature.com
Refractive error is the most common eye disorder worldwide and is a prominent cause of
blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The …

[HTML][HTML] Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future

PG Hysi, R Wojciechowski, JS Rahi… - … & visual science, 2014 - tvst.arvojournals.org
The investigation of the genetic basis of refractive error and myopia entered a new stage
with the introduction of genome-wide association studies (GWAS). Multiple GWAS on many …

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

MS Tedja, R Wojciechowski, PG Hysi, N Eriksson… - Nature …, 2018 - nature.com
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an
increasingly common cause of blindness. This genome-wide association meta-analysis in …

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

AP Khawaja, JN Cooke Bailey, NJ Wareham… - Nature …, 2018 - nature.com
Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the
disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is …

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

JE Craig, X Han, A Qassim, M Hassall… - Nature …, 2020 - nature.com
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be
prevented through timely diagnosis and treatment. We characterize optic nerve photographs …

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

PG Hysi, CY Cheng, H Springelkamp, S Macgregor… - Nature …, 2014 - nature.com
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and
variability in IOP might herald glaucomatous development or progression. We report the …

[PDF][PDF] Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

CY Cheng, M Schache, MK Ikram, TL Young… - The American Journal of …, 2013 - cell.com
Refractive errors are common eye disorders of public health importance worldwide. Ocular
axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia …

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

PG Hysi, H Choquet, AP Khawaja, R Wojciechowski… - Nature …, 2020 - nature.com
Refractive errors, in particular myopia, are a leading cause of morbidity and disability
worldwide. Genetic investigation can improve understanding of the molecular mechanisms …

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

H Springelkamp, AI Iglesias, A Mishra… - Human molecular …, 2017 - academic.oup.com
Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable
disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease …