Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities
PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration
PS Mettu, AR Wielgus, SS Ong, SW Cousins - Molecular aspects of …, 2012 - Elsevier
Age-related macular degeneration (AMD) represents the leading cause of vision loss in the
elderly. Accumulation of lipid-and protein-rich deposits under the retinal pigment epithelium …
elderly. Accumulation of lipid-and protein-rich deposits under the retinal pigment epithelium …
[HTML][HTML] Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization
DG Espinosa-Heidmann, IJ Suner… - … & visual science, 2003 - iovs.arvojournals.org
purpose. Macrophage recruitment to the choroid has been proposed to contribute to the
pathogenesis of choroidal neovascularization (CNV) in AMD. The study was conducted to …
pathogenesis of choroidal neovascularization (CNV) in AMD. The study was conducted to …
Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images
PP Srinivasan, LA Kim, PS Mettu… - Biomedical optics …, 2014 - opg.optica.org
We present a novel fully automated algorithm for the detection of retinal diseases via optical
coherence tomography (OCT) imaging. Our algorithm utilizes multiscale histograms of …
coherence tomography (OCT) imaging. Our algorithm utilizes multiscale histograms of …
Endophthalmitis after penetrating trauma: risk factors and visual acuity outcomes
WS Thompson, PE Rubsamen, HW Flynn Jr… - Ophthalmology, 1995 - Elsevier
Purpose: To identify clinical characteristics that were associated with an increased incidence
of endophthalmitis in eyes with penetrating ocular trauma. Methods: In part 1, a retrospective …
of endophthalmitis in eyes with penetrating ocular trauma. Methods: In part 1, a retrospective …
Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema
SJ Chiu, MJ Allingham, PS Mettu… - Biomedical optics …, 2015 - opg.optica.org
We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers
on spectral domain optical coherence tomography images of eyes with diabetic macular …
on spectral domain optical coherence tomography images of eyes with diabetic macular …
Immunoregulatory mechanisms of the eye
JW Streilein, GA Wilbanks, SW Cousins - Journal of neuroimmunology, 1992 - Elsevier
Immune-priviledged sites, such as the internal compartments of the eye, and perhaps the
brain, are physiological adaptations that act to modify systemic immune responses such that …
brain, are physiological adaptations that act to modify systemic immune responses such that …
Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor
AW Taylor, JW Streilein, SW Cousins - Current eye research, 1992 - Taylor & Francis
The aqueous humor of the eye contains factors that regulate immunological responses
within the immunosuppressive ocular microenvironment. Besides TGF-β, the proteins in the …
within the immunosuppressive ocular microenvironment. Besides TGF-β, the proteins in the …
Risks of mortality, myocardial infarction, bleeding, and stroke associated with therapies for age-related macular degeneration
LH Curtis, BG Hammill, KA Schulman… - Archives of …, 2010 - jamanetwork.com
Objective To examine associations between therapies for age-related macular degeneration
and risks of all-cause mortality, incident myocardial infarction, bleeding, and incident stroke …
and risks of all-cause mortality, incident myocardial infarction, bleeding, and incident stroke …
[HTML][HTML] Cigarette smoke–related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD
DG Espinosa-Heidmann, IJ Suner… - … & visual science, 2006 - arvojournals.org
purpose. Oxidative injury to the retinal pigment epithelium (RPE) has been proposed to be
an important injury stimulus relevant to the accumulation of subretinal deposits in age …
an important injury stimulus relevant to the accumulation of subretinal deposits in age …