[HTML][HTML] Immune privilege and eye-derived T-regulatory cells

H Keino, S Horie, S Sugita - Journal of immunology research, 2018 - hindawi.com
Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …

[HTML][HTML] Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behcet's disease

S Sugita, Y Kawazoe, A Imai, Y Yamada… - Arthritis research & …, 2012 - Springer
Introduction The purpose of this study was to determine whether anti-tumour necrosis factor
alpha (anti-TNF-α) antibody, infliximab, can inhibit T helper 17 (Th17) differentiation in …

Retinal pigment epithelium-derived CTLA-2α induces TGFβ-producing T regulatory cells

S Sugita, S Horie, O Nakamura, Y Futagami… - The Journal of …, 2008 - journals.aai.org
T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-
triggered activation, and instead acquire the capacity to suppress the activation of bystander …

Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease

T Kawaguchi, S Horie, N Bouchenaki… - International …, 2010 - Springer
Purpose To evaluate clinical and angiographic differences in patients with Vogt-Koyanagi-
Harada (VKH) disease during the early 4-month treatment phase with high-or medium-dose …

[HTML][HTML] Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of …

J Liu, DA Copland, S Horie, WK Wu, M Chen, Y Xu… - PloS one, 2013 - journals.plos.org
Whilst data recognise both myeloid cell accumulation during choroidal neovascularisation
(CNV) as well as complement activation, none of the data has presented a clear explanation …

[HTML][HTML] Role of IL-22–and TNF-α–Producing Th22 Cells in Uveitis Patients with Behçet's Disease

S Sugita, Y Kawazoe, A Imai, T Kawaguchi… - The Journal of …, 2013 - journals.aai.org
Behçet's disease is a systemic inflammatory disorder with recurrent episodes of oral
ulceration, skin lesions, genital ulceration, and intraocular inflammation (uveitis). The …

[HTML][HTML] T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions

S Sugita, Y Usui, S Horie, Y Futagami… - … & visual science, 2009 - arvojournals.org
purpose. To determine whether retinal pigment epithelial (RPE) cells can inhibit in vitro T-
cell activation during inflammatory conditions. methods. Primary cultured RPE cells were …

Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients

T Kawaguchi, A Hanada, S Horie, Y Sugamoto… - Japanese journal of …, 2007 - Springer
Purpose To evaluate the diagnostic values of ocular signs and systemic investigations in
ocular sarcoidosis, in a retrospective case–control study. Methods Subjects were 67 …

Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete

S Kido, S Sugita, S Horie, M Miyanaga… - British journal of …, 2008 - bjo.bmj.com
Aim: To investigative whether clinical manifestations of anterior uveitis are associated with
the viral load of varicella zoster virus (VZV) in the aqueous humor in patients with herpes …

Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR

S Sugita, N Shimizu, K Watanabe… - British journal of …, 2011 - bjo.bmj.com
Aim To measure the bacterial genome in ocular fluids and to analyse the clinical relevance
of infectious endophthalmitis. Methods Nineteen ocular fluid samples (eight aqueous …