[HTML][HTML] Immune privilege and eye-derived T-regulatory cells
H Keino, S Horie, S Sugita - Journal of immunology research, 2018 - hindawi.com
Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …
replicate after destructive inflammation. Ocular immune privilege provides the eye with …
[HTML][HTML] Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behcet's disease
S Sugita, Y Kawazoe, A Imai, Y Yamada… - Arthritis research & …, 2012 - Springer
Introduction The purpose of this study was to determine whether anti-tumour necrosis factor
alpha (anti-TNF-α) antibody, infliximab, can inhibit T helper 17 (Th17) differentiation in …
alpha (anti-TNF-α) antibody, infliximab, can inhibit T helper 17 (Th17) differentiation in …
Retinal pigment epithelium-derived CTLA-2α induces TGFβ-producing T regulatory cells
S Sugita, S Horie, O Nakamura, Y Futagami… - The Journal of …, 2008 - journals.aai.org
T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-
triggered activation, and instead acquire the capacity to suppress the activation of bystander …
triggered activation, and instead acquire the capacity to suppress the activation of bystander …
Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease
T Kawaguchi, S Horie, N Bouchenaki… - International …, 2010 - Springer
Purpose To evaluate clinical and angiographic differences in patients with Vogt-Koyanagi-
Harada (VKH) disease during the early 4-month treatment phase with high-or medium-dose …
Harada (VKH) disease during the early 4-month treatment phase with high-or medium-dose …
[HTML][HTML] Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of …
Whilst data recognise both myeloid cell accumulation during choroidal neovascularisation
(CNV) as well as complement activation, none of the data has presented a clear explanation …
(CNV) as well as complement activation, none of the data has presented a clear explanation …
[HTML][HTML] Role of IL-22–and TNF-α–Producing Th22 Cells in Uveitis Patients with Behçet's Disease
S Sugita, Y Kawazoe, A Imai, T Kawaguchi… - The Journal of …, 2013 - journals.aai.org
Behçet's disease is a systemic inflammatory disorder with recurrent episodes of oral
ulceration, skin lesions, genital ulceration, and intraocular inflammation (uveitis). The …
ulceration, skin lesions, genital ulceration, and intraocular inflammation (uveitis). The …
[HTML][HTML] T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions
S Sugita, Y Usui, S Horie, Y Futagami… - … & visual science, 2009 - arvojournals.org
purpose. To determine whether retinal pigment epithelial (RPE) cells can inhibit in vitro T-
cell activation during inflammatory conditions. methods. Primary cultured RPE cells were …
cell activation during inflammatory conditions. methods. Primary cultured RPE cells were …
Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients
T Kawaguchi, A Hanada, S Horie, Y Sugamoto… - Japanese journal of …, 2007 - Springer
Purpose To evaluate the diagnostic values of ocular signs and systemic investigations in
ocular sarcoidosis, in a retrospective case–control study. Methods Subjects were 67 …
ocular sarcoidosis, in a retrospective case–control study. Methods Subjects were 67 …
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete
S Kido, S Sugita, S Horie, M Miyanaga… - British journal of …, 2008 - bjo.bmj.com
Aim: To investigative whether clinical manifestations of anterior uveitis are associated with
the viral load of varicella zoster virus (VZV) in the aqueous humor in patients with herpes …
the viral load of varicella zoster virus (VZV) in the aqueous humor in patients with herpes …
Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR
S Sugita, N Shimizu, K Watanabe… - British journal of …, 2011 - bjo.bmj.com
Aim To measure the bacterial genome in ocular fluids and to analyse the clinical relevance
of infectious endophthalmitis. Methods Nineteen ocular fluid samples (eight aqueous …
of infectious endophthalmitis. Methods Nineteen ocular fluid samples (eight aqueous …