Alterations in non-enzymatic biochemistry in uremia: Origin and significance of “carbonyl
stress” in long-term uremic complications. Advanced glycation end products (AGEs), formed …

The uremic syndrome is usually attributed to the retention of a variety of compounds as a
result of a deficient renal clearance. These retention solutes are taken to induce biochemical …

In 1968, Berggard and Beam(1) isolated f32-microglobulin (J32m). It is a 100-amino acid
single polypeptide chain, with a globular structure maintained by a disulfide bond linking two …

Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic disease characterized
by abnormal blood cell populations in which the biosynthesis of the …

Acrolein (CH2= CH—CHO) is known as a ubiquitous pollutant in the environment. Here we
show that this notorious aldehyde is not just a pollutant, but also a lipid peroxidation product …

In a longitudinal clinical study to compare two groups, the primary end point is often the time
to a specific event (eg, disease progression, death). The hazard ratio estimate is routinely …

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many
proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of …

Advanced glycation end products (AGEs) include a variety of protein adducts whose
accumulation alters the structure and function of tissue proteins and stimulates cellular …

beta 2-Microglobulin (beta 2M) is a major constituent of amyloid fibrils in hemodialysis-
associated amyloidosis, a complication of long-term hemodialysis patients. Amyloid fibril …

Implication of an increased oxidative stress in the formation of advanced glycation end
products in patients with end-stage renal failure. Recent studies have demonstrated a …