The frontiers of precision medicine have been revolutionized by the development of
Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing …

Retinal and choroidal neovascularization are a major cause of significant visual impairment,
worldwide. Understanding the various factors involved in the accompanying …

Precision medicine seeks to treat disease with molecular specificity. Advances in genome
sequence analysis, gene delivery, and genome surgery have allowed clinician-scientists to …

Background Phase 1 studies have shown potential benefit of gene replacement in RPE65-
mediated inherited retinal dystrophy. This phase 3 study assessed the efficacy and safety of …

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …

CRISPR–Cas9 editing shows promise for correcting disease-causing mutations. For
example, in a recent study we used CRISPR-Cas9 for sight restoration in blind rd1 mice by …

PURPOSE: To evaluate the outcome of intravitreal injection of aflibercept in cases with
exudative age-related macular degeneration,(AMD) resistant to injections of bevacizumab or …

PURPOSE: To compare the performance of automated diabetic retinopathy (DR) detection,
using the algorithm that won the 2009 Retinopathy Online Challenge Competition in 2009 …

Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially
be used as a source of autologous cells for transplantation in retinal disease. Patient …

Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ …