[HTML][HTML] Characteristics of pachychoroid diseases and age-related macular degeneration: multimodal imaging and genetic backgrounds

K Yamashiro, Y Hosoda, M Miyake, S Ooto… - Journal of clinical …, 2020 - mdpi.com
The emergence of pachychoroid disease is changing the concept of age-related macular
degeneration (AMD). The concept of pachychoroid diseases was developed through clinical …

CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy

Y Hosoda, M Yoshikawa, M Miyake… - Proceedings of the …, 2018 - National Acad Sciences
Central serous chorioretinopathy (CSC) is a common disease affecting younger people and
may lead to vision loss. CSC shares phenotypic overlap with age-related macular …

[HTML][HTML] CCDC102B confers risk of low vision and blindness in high myopia

Y Hosoda, M Yoshikawa, M Miyake, Y Tabara… - Nature …, 2018 - nature.com
The incidence of high myopia is increasing worldwide with myopic maculopathy, a
complication of myopia, often progressing to blindness. Our two-stage genome-wide …

[HTML][HTML] Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

Y Hosoda, M Miyake, RL Schellevis, CJF Boon… - Communications …, 2019 - nature.com
The recently emerged pachychoroid concept has changed the understanding of age-related
macular degeneration (AMD), which is a major cause of blindness; recent studies attributed …

Hypothetical pathogenesis of age-related macular degeneration and pachychoroid diseases derived from their genetic characteristics

K Yamashiro, Y Hosoda, M Miyake… - Japanese Journal of …, 2020 - Springer
Genetic studies have investigated the pathogenesis of age-related macular degeneration
(AMD). The pachychoroid concept has recently garnered attention as a possible explanation …

Myopia prevalence and ocular biometry features in a general Japanese population: the Nagahama Study

S Nakao, M Miyake, Y Hosoda, E Nakano, Y Mori… - Ophthalmology, 2021 - Elsevier
Purpose To describe the distribution of ocular biometry and refraction in Japanese adults.
Design Cross-sectional analysis of a prospective cohort study. Participants A total of 9850 …

[HTML][HTML] Foveal photoreceptor deformation as a significant predictor of postoperative visual outcome in idiopathic epiretinal membrane surgery

Y Hosoda, S Ooto, M Hangai, A Oishi… - … & Visual Science, 2015 - tvst.arvojournals.org
Purpose: The purpose of this study was to determine whether the outer nuclear layer (ONL)
deformation detected by spectral-domain optical coherence tomography (SD-OCT) is …

Genome-wide association study in Asians identifies novel loci for high myopia and highlights a nervous system role in its pathogenesis

A Meguro, T Yamane, M Takeuchi, M Miyake, Q Fan… - Ophthalmology, 2020 - Elsevier
Purpose To identify novel susceptibility loci for high myopia. Design Genome-wide
association study (GWAS) followed by replication and meta-analysis. Participants A total of …

[HTML][HTML] Deep phenotype unsupervised machine learning revealed the significance of pachychoroid features in etiology and visual prognosis of age-related macular …

Y Hosoda, M Miyake, K Yamashiro, S Ooto… - Scientific Reports, 2020 - nature.com
Unsupervised machine learning has received increased attention in clinical research
because it allows researchers to identify novel and objective viewpoints for diseases with …

Relationship between retinal lesions and inward choroidal bulging in Vogt-Koyanagi-Harada disease

Y Hosoda, A Uji, M Hangai, S Morooka… - American Journal of …, 2014 - Elsevier
Purpose To investigate the correlation between choroidal and retinal lesions in eyes with
acute Vogt-Koyanagi-Harada disease (VKH) using optical coherence tomography (OCT) by …