Subgenome parallel selection is associated with morphotype diversification and convergent crop domestication in Brassica rapa and Brassica oleracea

F Cheng, R Sun, X Hou, H Zheng, F Zhang, Y Zhang… - Nature …, 2016 - nature.com
Brassica species, including crops such as cabbage, turnip and oilseed, display enormous
phenotypic variation. Brassica genomes have all undergone a whole-genome triplication …

Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy

D Cao, D Yang, Z Huang, Y Zeng, J Wang, Y Hu… - Acta …, 2018 - Springer
Aims To investigate changes in retinal vascular plexuses and choriocapillaris in patients
with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls …

Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies

F Tan, X Shen, D Wang, G Xie, X Zhang, L Ding, Y Hu… - Lung cancer, 2012 - Elsevier
Icotinib, one of the leading compounds selected from our compound library, was found to be
a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) …

Early retinal neurovascular impairment in patients with diabetes without clinically detectable retinopathy

Y Zeng, D Cao, H Yu, D Yang, X Zhuang… - British Journal of …, 2019 - bjo.bmj.com
Aims To investigate the function and the corresponding neurovascular structures in patients
with diabetes without clinically detectable retinopathy. Methods Sixty-six patients with type 2 …

Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors

S Hu, G Xie, DX Zhang, C Davis, W Long, Y Hu… - Bioorganic & medicinal …, 2012 - Elsevier
Crown ether fused anilinoquinazoline analogues were synthesized as novel epidermal
growth factor receptor (EGFR) tyrosine kinase inhibitors. Representative compounds …

Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients

M He, W Wang, H Yu, D Wang, D Cao, Y Zeng, Q Wu… - Acta …, 2020 - Springer
Aims To compare circular (circRNA) expression levels in the vitreous humour between PDR
(proliferative diabetic retinopathy) and the control groups. Methods The present study …

A transposon insertion in FLOWERING LOCUS T is associated with delayed flowering in Brassica rapa

X Zhang, L Meng, B Liu, Y Hu, F Cheng, J Liang… - Plant Science, 2015 - Elsevier
Long days and vernalization accelerate the transition from vegetative growth to reproductive
growth in Brassica rapa. Bolting before plants reach the harvesting stage is a serious …

EBD: an eye biomarker database

X Zhang, L Kong, S Liu, X Zhang, X Shang, Z Zhu… - …, 2023 - academic.oup.com
Motivation Many ophthalmic disease biomarkers have been identified through
comprehensive multiomics profiling, and hold significant potential in advancing the …

[HTML][HTML] Shared genetic architecture between the two neurodegenerative diseases: Alzheimer's disease and glaucoma

C Zheng, S Liu, X Zhang, Y Hu, X Shang… - Frontiers in aging …, 2022 - frontiersin.org
Background: Considered the representatives of neurodegenerative diseases, Alzheimer's
disease and glaucoma are complicated progressive neuropathies affected by both genetic …

[HTML][HTML] Comprehensive analysis of vitreous chemokines involved in ischemic retinal vein occlusion

Y Zeng, D Cao, H Yu, X Zhuang, D Yang, Y Hu… - Molecular …, 2019 - ncbi.nlm.nih.gov
Methods The vitreous humor was collected at the start of 23-gauge pars plana vitrectomy
from patients with ischemic RVO and patients with idiopathic preretinal membranes (PRMs) …