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Original Article
Activated protein C resistance in patients with central retinal vein occlusion
  1. J Larssona,
  2. A Sellmanb,
  3. B Bauera
  1. aDepartment of Ophthalmology, Lund University Hospital, Sweden, bMedical Center Hospital of Helsingborg, Sweden
  1. Dr J Larsson, Department of Ophthalmology, Lund University Hospital, S-221 85 Lund, Sweden.

Abstract

AIM/BACKGROUND A new defect in the anticoagulant system has recently been discovered—activated protein C resistance. The frequency of this disorder has been shown to be increased in young patients (<50 years of age) with central retinal vein occlusion. This study was carried out to determine if there was any overrepresentation of activated protein C resistance in patients >50 years of age with central retinal vein occlusion.

METHODS Blood samples were obtained from 83 patients >50 years of age and with a history of central retinal vein occlusion. The blood samples were analysed for activated protein C resistance with standard clinical laboratory methods.

RESULTS In this material 11% of the patients were resistant to activated protein C. The normal incidence of activated protein C resistance in the same geographical area is 10–11%.

CONCLUSION Activated protein C resistance does not seem to be a cause of central retinal vein occlusion in people older than 50 years.

  • central retinal vein occlusion
  • activated protein C resistance

https://doi.org/10.1136/bjo.81.10.832

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