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Relationship between the number of cytomegalovirus in anterior chamber and severity of anterior segment inflammation

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To characterize the cytomegalovirus-associated anterior segment inflammation and to determine whether the number of cytomegalovirus is significantly correlated with the disease characteristics.

Methods

Retrospective consecutive case series. Seventy-three patients with refractory anterior segment inflammation due to iridocyclitis, corneal endotheliitis and keratouveitis were studied. All the patients were suspected to have cytomegalovirus infection and had undergone real-time PCR of the aqueous humor to determine the amount of cytomegalovirus DNA.

Results

Cytomegalovirus DNA was detected in 24 of the 73 cases. The cytomegalovirus copy number was significantly correlated with the number of recurrent episodes and glaucoma treatment levels, but was not significantly correlated with the disease type. A high cytomegalovirus copy number was a significant risk factor for IOP elevation [Odds ratio (OR) per logarithm CMV amount: 2.5 (95 % confidence interval (CI) 1.1–5.4), presence of coin-shaped lesions (2.3 (1.3–4.0)), recurrent inflammation (2.1 (1.3–3.5)), and reduction of endothelial cell densities (1.7 (1.2–2.5))]. An IOP elevation [OR 18.2 (95 % CI 2.2–153.0)], reduction of endothelial cell densities [13.2 (2.9–60.0)], and recurrent inflammations [11.9 (2.5–56.6)], but not the disease type, were significant predictors of the presence of >103 copies/ml cytomegalovirus in the aqueous.

Conclusions

Measurements of the cytomegalovirus DNA amount is useful for evaluating the severity of the anterior segment inflammation.

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Acknowledgments

The authors thank Dr. Duco Hamasaki for editing this article. This work was supported by a grant from the Ministry of Health, Labor and Welfare of Japan: H23-Nanti-Ippan-074.

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Authors and Affiliations

  1. Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan

    Michiko Kandori, Dai Miyazaki, Keiko Yakura, Naoki Komatsu, Chizu Touge, Ryoko Ishikura & Yoshitsugu Inoue

Authors
  1. Michiko Kandori
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  2. Dai Miyazaki
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  3. Keiko Yakura
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  4. Naoki Komatsu
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  5. Chizu Touge
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  6. Ryoko Ishikura
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  7. Yoshitsugu Inoue
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Corresponding author

Correspondence to Dai Miyazaki.

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Kandori, M., Miyazaki, D., Yakura, K. et al. Relationship between the number of cytomegalovirus in anterior chamber and severity of anterior segment inflammation. Jpn J Ophthalmol 57, 497–502 (2013). https://doi.org/10.1007/s10384-013-0268-2

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  • DOI: https://doi.org/10.1007/s10384-013-0268-2

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