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Clinical Spectrum of Lamellar Macular Defects Including Pseudoholes and Pseudocysts Defined By Optical Coherence Tomography
  1. Jennifer C Chen (jc.chen{at},
  2. Lawrence R Lee
  1. City Eye Centre, Australia
  2. City Eye Centre, Australia


    Objective: To present the clinical spectrum of lamellar macular defects and describe the different subtypes based on their OCT configuration and visual prognosis.

    Methods: The retrospective observational case series reviewed OCT scans of 92 eyes with lamellar macular defects. Lamellar macular defects were categorized into subtypes of macular pseudohole (MPH), lamellar macular hole (LMH), and foveal pseudocyst (FP) according to their OCT morphology. The defects were quantitatively characterized in terms of base diameter, depth, central foveal thickness, and examined for the presence of associated epiretinal membranes (ERM).

    Results: Visual acuity (VA) was significantly correlated with the central foveal thickness and depth of the lamellar defect. MPH was associated with better VA compared with LMH and FP. MPH was of smaller base diameter and had greater central foveal thickness than that of LMH and FP. Fifty-percent of all lamellar defects had an associated ERM.

    Conclusions: Different profiles of lamellar macular defects were characterized and quantified by OCT. Deeper and wider lamellar defects were associated with poorer visual outcome. Such objective parameters lamellar macular defects are of value when explaining to patients regarding their decreased acuity. Future prospective investigations are required to study the natural history of lamellar defects of different aetiology and surgical indications.

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