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Clinical science
Anterior chamber particles are associated with reduction of intraocular pressure after selective laser trabeculoplasty
  1. Alexei N Kulikov,
  2. Dmitrii S Maltsev,
  3. Alina A Kazak,
  4. Maria A Burnasheva
  1. Ophthalmology, Military Medical Academy, Saint Petersburg, Russian Federation
  1. Correspondence to Dr Dmitrii S Maltsev, Ophthalmology, Military Medical Academy, 194044 Saint-Petersburg, Lebedeva Str. 6, Russian Federation; glaz.med{at}yandex.ru

Abstract

Purpose To study the correlation between intraocular pressure (IOP) reduction and the number of hyper-reflective particles appearing in the anterior chamber following selective laser trabeculoplasty (SLT).

Material and methods In this prospective interventional study, we included primary open-angle glaucoma patients. All participants received a standardised SLT session, which consisted of 100 pulses of 0.9 mJ over 360°. Anterior segment optical coherence tomography (4×4 mm volume scan, 101 horizontal cross-sectional scans) and applanation tonometry were performed before SLT and 15 min, 1 day, 1 week, 1 month and 3 months after. Particles were counted on cross-sectional scans using a standardised algorithm.

Results In this study, we included 25 patients (25 eyes), 14 males and 11 females, with a mean age of 68.9±10.5 and baseline IOP of 21.4±4.5 mm Hg. IOP at month 1 and month 3 after SLT was 18.0±4.0 and 17.4±3.3 mm Hg, respectively. The mean number of anterior chamber particles before and 15 min after SLT was 0.62±0.2 and 7.1±2.0 particles/mm2, respectively (p=0.036). There was a statistically significant correlation between the mean number of anterior chamber particles 15 min after SLT and IOP reduction at 1 month (r=0.62, p=0.03) and 3 months (r=0.71, p=0.01).

Conclusion The number of the anterior chamber particles graded using anterior segment optical coherence tomography after the procedure correlates with the IOP-lowering effect of SLT.

  • anterior chamber
  • glaucoma
  • imaging
  • intraocular pressure
  • treatment lasers

https://doi.org/10.1136/bjophthalmol-2019-315445

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    Footnotes

    • Contributors DSM, ANK and MAB designed the study. DSM, MAB and AAK collected the data. DSM, AAK and ANK analysed the data. DSM, MAB and AAK drafted the manuscript. DSM, ANK, MAB and AAK critically reviewed and approved the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available on reasonable request. The data (raw OCT files and datasheets) are available from DSM. Request via e-mail glaz.med@yandex.ru.