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B cell monoclonality of intraocular lymphoma and breast lymphoma
  1. K Ohta1,
  2. K Sano2,
  3. T Hirano1,
  4. T Sugimoto1,
  5. T Kikuchi3
  1. 1
    Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan
  2. 2
    Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan
  3. 3
    Department of Instrumental Analysis Research Center for Human and Environmental Science, Shinshu University School of Medicine, Matsumoto, Japan
  1. K Ohta, Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621 Nagano, Japan; kohta{at}hsp.md.shinshu-u.ac.jp

https://doi.org/10.1136/bjo.2007.121863

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    B cell monoclonal gene rearrangements have been reported in several cases of primary intraocular lymphoma and primary central nervous system lymphomas. Such molecular analysis has been performed on only one case of a primary testicular and a metastatic intraocular lymphoma. However, the gene rearrangements differed at the two sites. We present a case in which B cell monoclonality was found in an intraocular lymphoma and a primary breast lymphoma. Intraocular non-Hodgkin’s lymphomas are uncommon malignant tumours derived from two types of lymphomas; a primary central nervous system lymphoma (PCNSL) and a systemic lymphoma. Compared with primary intraocular lymphomas (PIOLs), the prevalence of metastatic systemic lymphomas is much lower.1 2 The diagnosis of …

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    • Competing interests: None.